{"id":16006,"date":"2025-12-10T15:11:07","date_gmt":"2025-12-10T13:11:07","guid":{"rendered":"https:\/\/endocrinesurgeon.gr\/adenoma-parathreioeidous\/"},"modified":"2026-01-30T10:53:30","modified_gmt":"2026-01-30T08:53:30","slug":"parathyroid-adenoma","status":"publish","type":"page","link":"https:\/\/endocrinesurgeon.gr\/en\/parathyroid-adenoma\/","title":{"rendered":"Parathyroid Adenoma"},"content":{"rendered":"<p>[vc_row][vc_column][vc_column_text]<\/p>\n<p style=\"text-align: right;\"><a class=\"cmsmasters-icon-print-1\"><span style=\"margin-left: 7px;\">\u0395\u03ba\u03c4\u03cd\u03c0\u03c9\u03c3\u03b7<\/span><\/a><\/p>\n<p>[\/vc_column_text][vc_tta_accordion color=&#8221;sky&#8221; c_icon=&#8221;chevron&#8221; active_section=&#8221;1&#8243; no_fill=&#8221;true&#8221; collapsible_all=&#8221;true&#8221;][vc_tta_section title=&#8221;What Is a Parathyroid Adenoma&#8221; tab_id=&#8221;1615975356574-814f1578-a50b&#8221;][vc_column_text]<span style=\"font-weight: 400;\">A parathyroid adenoma is a condition in which one of the <\/span><a href=\"https:\/\/endocrinesurgeon.gr\/en\/parathyroid\/\"><b>parathyroid glands<\/b><\/a><span style=\"font-weight: 400;\"> becomes enlarged. This leads to uncontrolled and autonomous secretion of <\/span><b>Parathyroid Hormone (PTH)<\/b><span style=\"font-weight: 400;\">, the hormone responsible for regulating calcium levels in the blood.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The resulting condition is known as <\/span><b>primary hyperparathyroidism<\/b><span style=\"font-weight: 400;\">.<\/span>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;What Is the Function of the Parathyroid Glands&#8221; tab_id=&#8221;1615975356596-08586a48-adda&#8221;][vc_column_text]<span style=\"font-weight: 400;\">The <\/span><b>parathyroid glands<\/b><span style=\"font-weight: 400;\"> are four small but extremely important <\/span><b>endocrine glands,<\/b><span style=\"font-weight: 400;\"> usually located on the posterior surface of the thyroid. Their primary role is the <\/span><b>production and regulation of Parathyroid Hormone (PTH)<\/b><span style=\"font-weight: 400;\">, which is essential for maintaining calcium and phosphorus balance in the body.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Through PTH, the parathyroid glands control key functions such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Calcium absorption from the intestine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Calcium release from the bones<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Regulation of kidney function related to calcium<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The proper functioning of these glands <\/span><b>is critical for normal<\/b> <b>muscle, nerve, and heart function<\/b><span style=\"font-weight: 400;\">. When one of the glands becomes overactive, as occurs in an adenoma, PTH production increases excessively, leading to <\/span><b>significant disturbances<\/b><span style=\"font-weight: 400;\"> in the body.<\/span>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;What Symptoms Does a Parathyroid Adenoma Cause&#8221; tab_id=&#8221;1615975445991-abbe6e0b-76e0&#8243;][vc_column_text]<span style=\"font-weight: 400;\">Unfortunately, this condition usually does not cause obvious or pronounced symptoms. Patients may experience <\/span><b>vague discomfort, which they often attribute to other causes, while associated problems may incorrectly go unlinked to the presence of the adenoma.<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Commonly reported symptoms include:<\/span><\/p>\n<ul>\n<li aria-level=\"1\"><b>Easy fatigue and muscle weakness<\/b><\/li>\n<li aria-level=\"1\"><b>Musculoskeletal pain<\/b><\/li>\n<li aria-level=\"1\"><b>Kidney stones<\/b><span style=\"font-weight: 400;\"> or ureteral stones<\/span><\/li>\n<li aria-level=\"1\"><b>Osteopenia and osteoporosis<\/b><span style=\"font-weight: 400;\">, increasing fracture risk<\/span><\/li>\n<li aria-level=\"1\"><b>Gastrointestinal symptoms,<\/b><span style=\"font-weight: 400;\"> such as constipation, nausea, unexplained vomiting, and peptic ulcers<\/span><\/li>\n<li aria-level=\"1\"><b>High blood pressure and cardiac arrhythmias<\/b><\/li>\n<li aria-level=\"1\"><b>Neuropsychiatric symptoms,<\/b><span style=\"font-weight: 400;\"> including confusion, fatigue, depression, behavioral changes, and memory disturbances<\/span><\/li>\n<li aria-level=\"1\"><b>Frequent urination (polyuria)<\/b><span style=\"font-weight: 400;\"> and increased thirst<\/span><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;What Causes a Parathyroid Adenoma&#8221; tab_id=&#8221;1615975481588-25200828-4edd&#8221;][vc_column_text]<span style=\"font-weight: 400;\">In the vast majority of cases, a parathyroid adenoma occurs as a <\/span><b>sporadic, isolated event of unknown cause<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Less commonly, it may be part of a genetic syndrome, such as Multiple Endocrine Neoplasia (MEN), or related to glandular hyperplasia, and in rare instances, it may be associated with a malignant tumor.<\/span>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;How Is a Parathyroid Adenoma Diagnose&#8221; tab_id=&#8221;1615975590436-b57265fb-fab9&#8243;][vc_column_text]<b>The diagnosis of a parathyroid adenoma<\/b><span style=\"font-weight: 400;\"> essentially involves two phases:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Firstly, diagnosing<\/span><b> the disorder caused by the adenoma<\/b><span style=\"font-weight: 400;\">, namely <\/span><b>primary hyperparathyroidism<\/b><span style=\"font-weight: 400;\">.<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">The family physician, internist, or endocrinologist, based on clinical suspicion, confirms the diagnosis by identifying elevated or borderline Parathyroid Hormone (PTH) levels in the blood, high or borderline calcium levels, normal or low phosphorus levels<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\">Secondly,<b> locating the adenoma anatomically to determine the exact position of the parathyroid gland responsible for the disorder.<\/b><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Which Tests Are Needed to Locate a Parathyroid Adenoma&#8221; tab_id=&#8221;1769696983186-9682442a-febb&#8221;][vc_column_text]<span style=\"font-weight: 400;\">Locating a parathyroid adenoma <\/span><b>is not always straightforward<\/b><span style=\"font-weight: 400;\">, as each imaging method has its own strengths and limitations regarding sensitivity and specificity. Often, a <\/span><b>combination of two or more tests<\/b><span style=\"font-weight: 400;\"> is required to improve diagnostic accuracy. The most commonly used tests to locate a parathyroid adenoma include:<\/span><\/p>\n<ul>\n<li aria-level=\"1\"><b>Neck ultrasound<\/b><\/li>\n<li aria-level=\"1\"><b>Parathyroid scintigraphy with technetium-99m (Sestamibi)<\/b><\/li>\n<li aria-level=\"1\"><span style=\"font-weight: 400;\">Four-dimensional CT (4D-CT)<\/span><\/li>\n<li aria-level=\"1\"><span style=\"font-weight: 400;\">PET\/CT or MRI<\/span><\/li>\n<li aria-level=\"1\"><span style=\"font-weight: 400;\">Single-photon emission computed tomography (SPECT)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In practice, most cases rely primarily on the first two methods.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It is noteworthy that <\/span><b>sometimes one of these imaging tests (ultrasound or scintigraphy) may fail to visualize the lesion, or the two tests may disagree on the exact location of the adenoma.<\/b><span style=\"font-weight: 400;\"> In some cases, ultrasound alone is sufficient to clearly identify the lesion.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">At this point, it should be emphasized that parathyroid adenoma surgeries often rely not only on preoperative imaging, which may sometimes be inconclusive, <\/span><b>but primarily<\/b><span style=\"font-weight: 400;\"> on the surgeon\u2019s experience and expertise in endocrine surgery. It is of great importance not only to evaluate<\/span><b> preoperative data<\/b><span style=\"font-weight: 400;\">, but above all, to rely on the surgeon\u2019s specialized training, skill, and experience to identify <\/span><b>intraoperatively<\/b><span style=\"font-weight: 400;\"> one or more adenomas and remove them with complete success.<\/span>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Can the Parathyroid Glands Have Multiple Adenomas&#8221; tab_id=&#8221;1615976016751-0a946bcb-71fc&#8221;][vc_column_text]<span style=\"font-weight: 400;\">Yes, though less common, the parathyroid glands can develop <\/span><b>multiple adenomas<\/b><span style=\"font-weight: 400;\"> in approximately <\/span><b>5\u201315% of cases<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Accurate preoperative diagnosis is crucial, combined with specialized surgical management. Successful treatment relies not only on the <\/span><b>surgeon\u2019s extensive experience<\/b><span style=\"font-weight: 400;\"> but is also enhanced by advanced surgical techniques, such as <\/span><b>intraoperative PTH measurement<\/b><span style=\"font-weight: 400;\"> and <\/span><b>frozen section (rapid) biopsy<\/b><span style=\"font-weight: 400;\">, among others.<\/span>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Is Parathyroid Adenoma Cancer?&#8221; tab_id=&#8221;1615976104393-438a3c43-b7c5&#8243;][vc_column_text]<b>No<\/b><span style=\"font-weight: 400;\">, a parathyroid adenoma is <\/span><b>not cancer<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">To clarify, although a parathyroid adenoma is a <\/span><b>benign tumor<\/b><span style=\"font-weight: 400;\"> and not a <\/span><b>carcinoma<\/b><span style=\"font-weight: 400;\">, its significant harmful effects, caused by excessive parathyroid hormone production, can adversely impact multiple organ systems, making it <\/span><b>medically important despite not being classified as malignant.<\/b>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;What Is the Appropriate Treatment for a Parathyroid Adenoma?&#8221; tab_id=&#8221;1765372280646-ec18b649-028c&#8221;][vc_column_text]<span style=\"font-weight: 400;\">The <\/span><b>definitive treatment<\/b><span style=\"font-weight: 400;\"> for a parathyroid adenoma is <\/span><b>surgical removal of the affected parathyroid gland (<a href=\"https:\/\/endocrinesurgeon.gr\/en\/parathyroidectomy\/\">parathyroidectomy<\/a>)<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This highly specialized procedure should be performed by an experienced endocrine surgeon. At our <\/span><b>Center of Excellence for Thyroid and Parathyroid Surgery<\/b><span style=\"font-weight: 400;\">, we have the privilege of treating these complex cases from across Greece. By applying a practically bloodless minimally invasive technique without a scalpel, combined with intraoperative PTH measurement, we provide a definitive cure for hundreds of patients, without sutures, without pain, and with a rapid return to daily life.<\/span>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Is There a Risk of Complications?&#8221; tab_id=&#8221;1765372297594-19296b2f-a4b8&#8243;][vc_column_text]<span style=\"font-weight: 400;\"><a href=\"https:\/\/endocrinesurgeon.gr\/en\/parathyroidectomy\/\">Parathyroidectomy<\/a> is a <\/span><b>highly<\/b> <b>delicate procedure<\/b> <b>that requires complete specialization and extensive experience from the surgeon.<\/b><\/p>\n<p><span style=\"font-weight: 400;\">A key aspect of this surgery is the surgeon\u2019s ability to intraoperatively identify the parathyroid adenoma and remove it safely. The risk of complications, such as hematoma or postoperative hoarseness, is rare when the operation is performed in a specialized Endocrine Surgery Center.<\/span><\/p>\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/endocrinesurgeon.gr\/en\/parathyroidectomy\/\">Parathyroidectomy<\/a> is a <\/span><b>safe procedure<\/b><span style=\"font-weight: 400;\"> that, in experienced hands, leads to the successful removal of the adenoma, providing a <\/span><b>definitive cure and full restoration of normal parathyroid function.<\/b>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;What to Expect After Parathyroid Surgery&#8221; tab_id=&#8221;1765372328457-1ec75718-e6ca&#8221;][vc_column_text]<span style=\"font-weight: 400;\">Recovery after <a href=\"https:\/\/endocrinesurgeon.gr\/en\/parathyroidectomy\/\">parathyroidectomy<\/a> is rapid, especially when minimally invasive techniques are used. Most patients <\/span><b>return to their daily activities within 24 hours<\/b><span style=\"font-weight: 400;\">, without pain or discomfort.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Immediate benefits include:<\/span><\/p>\n<ul>\n<li aria-level=\"1\"><b>Rapid drop in parathyroid hormone (PTH) levels during surgery<\/b><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Gradual normalization of calcium levels within hours to a day<\/b><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Improvement of symptoms such as fatigue, muscle weakness, neuropsychiatric disturbances, or kidney stones<\/b><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The body\u2019s smooth transition to normal calcium regulation after adenoma removal is supported by temporary supplementation with calcium and vitamin D, preventing postoperative hypocalcemia.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Full recovery is usually immediate, and <\/span><b>quality of life improves significantly within a short period.<\/b><\/p>\n<p><span style=\"font-weight: 400;\">For more information about parathyroid adenomas, <\/span><b>their causes<\/b><span style=\"font-weight: 400;\">, and treatment options, contact <\/span><b>Dr. Evangelos Karvounis<\/b><span style=\"font-weight: 400;\">, a leading <\/span><a href=\"https:\/\/endocrinesurgeon.gr\/en\/\"><span style=\"font-weight: 400;\">Endocrine Surgeon specializing in Thyroid and Parathyroid surgery<\/span><\/a><span style=\"font-weight: 400;\">, and Director at the Center of Excellence, Euroclinic Athens. With <\/span><b>extensive experience <\/b><span style=\"font-weight: 400;\">in the UK and the use of <\/span><b>innovative, minimally invasive techniques<\/b><span style=\"font-weight: 400;\">, he provides safe, bloodless surgeries with <\/span><b>rapid recovery<\/b><span style=\"font-weight: 400;\"> and a <\/span><b>patient-centered approach<\/b><span style=\"font-weight: 400;\">. <\/span><a href=\"https:\/\/endocrinesurgeon.gr\/en\/contact\/\"><span style=\"font-weight: 400;\">Book your appointment<\/span><\/a><span style=\"font-weight: 400;\"> today and entrust your health to an expert.<\/span>[\/vc_column_text][\/vc_tta_section][\/vc_tta_accordion][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] \u0395\u03ba\u03c4\u03cd\u03c0\u03c9\u03c3\u03b7 [\/vc_column_text][vc_tta_accordion color=&#8221;sky&#8221; c_icon=&#8221;chevron&#8221; active_section=&#8221;1&#8243; no_fill=&#8221;true&#8221; collapsible_all=&#8221;true&#8221;][vc_tta_section title=&#8221;What Is a Parathyroid Adenoma&#8221; tab_id=&#8221;1615975356574-814f1578-a50b&#8221;][vc_column_text]A parathyroid adenoma is a condition in which one of the parathyroid glands becomes enlarged. This leads to uncontrolled and autonomous secretion of Parathyroid Hormone (PTH), the hormone responsible for regulating calcium levels in the blood. The resulting condition is known as&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-16006","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Parathyroid Adenoma: Diagnosis &amp; Surgical Treatment | Karvounis<\/title>\n<meta name=\"description\" content=\"Parathyroid adenoma causes excess PTH and high calcium levels. 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