{"id":16001,"date":"2025-11-03T15:21:31","date_gmt":"2025-11-03T13:21:31","guid":{"rendered":"https:\/\/endocrinesurgeon.gr\/karkinos-thireoeidous\/"},"modified":"2026-01-30T10:45:26","modified_gmt":"2026-01-30T08:45:26","slug":"thyroid-cancer","status":"publish","type":"page","link":"https:\/\/endocrinesurgeon.gr\/en\/thyroid-cancer\/","title":{"rendered":"Thyroid Cancer"},"content":{"rendered":"<p>[vc_row][vc_column][vc_column_text]<\/p>\n<p style=\"text-align: right;\"><a class=\"cmsmasters-icon-print-1\"><span style=\"margin-left: 7px;\">\u0395\u03ba\u03c4\u03cd\u03c0\u03c9\u03c3\u03b7<\/span><\/a><\/p>\n<p>[\/vc_column_text][vc_tta_accordion color=&#8221;sky&#8221; c_icon=&#8221;chevron&#8221; active_section=&#8221;1&#8243; no_fill=&#8221;true&#8221; collapsible_all=&#8221;true&#8221;][vc_tta_section title=&#8221;What is thyroid cancer&#8221; tab_id=&#8221;1615975356574-814f1578-a50b&#8221;][vc_column_text]<span style=\"font-weight: 400;\">Thyroid cancer is a malignant neoplasm originating in the thyroid gland\u2014an endocrine gland located at the base of the neck that produces essential hormones. It is the most common cancer of the endocrine system.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It usually appears as a nodule or swelling in the neck and, in most cases, does not cause noticeable symptoms.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Early diagnosis and appropriate <\/span><b>treatment<\/b><span style=\"font-weight: 400;\"> typically lead to <\/span><b>extremely high cure rates<\/b><span style=\"font-weight: 400;\">, especially for the most common types of the disease.<\/span>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;How common is thyroid cancer&#8221; tab_id=&#8221;1615975356596-08586a48-adda&#8221;][vc_column_text]<span style=\"font-weight: 400;\">Thyroid cancer is relatively common (about 1\u20132% of all cancers), yet because of its excellent prognosis, it remains a rare cause of cancer-related death. Its incidence varies depending on geography, age, sex, and other factors.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Over the past decade, thyroid cancer has shown <\/span><b>the highest annual increase in incidence compared with other cancers. <\/b><span style=\"font-weight: 400;\">This is likely related both to environmental factors and to significant improvements in diagnostic imaging.<\/span>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Does thyroid cancer depend on age and sex&#8221; tab_id=&#8221;1615975445991-abbe6e0b-76e0&#8243;][vc_column_text]<span style=\"font-weight: 400;\">Thyroid cancer is 3\u20134 times more<\/span><b> common in women <\/b><span style=\"font-weight: 400;\">than in men, likely due to hormonal influences.<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">It is rare in children and adolescents and generally has a very favorable prognosis.<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">It can occur at any age, but it is most often diagnosed in individuals in their 40s and 50s.<\/span>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;What are the symptoms of thyroid cancer&#8221; tab_id=&#8221;1615975481588-25200828-4edd&#8221;][vc_column_text]<span style=\"font-weight: 400;\">In the vast majority of cases, thyroid cancer causes <\/span><b>NO symptoms at all<\/b><span style=\"font-weight: 400;\">.<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">It is often <\/span><b>detected incidentally <\/b><span style=\"font-weight: 400;\">as a thyroid nodule on ultrasound.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The tumor may develop silently, <\/span><b>without any warning symptoms for the patient.<\/b><\/p>\n<p><span style=\"font-weight: 400;\">In the small percentage of patients who develop <\/span><b>symptoms<\/b><span style=\"font-weight: 400;\">, these may include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A painless lump or swelling in the front of the neck<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Discomfort or atypical pain in the neck, sometimes radiating to nearby areas<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hoarseness or voice changes if the tumor affects the recurrent laryngeal nerve<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A sensation of tightness or pressure in the neck<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Difficulty swallowing (dysphagia) or a feeling of a foreign body in the throat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Persistent cough without respiratory infection or other obvious cause<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Breathing difficulty (dyspnea), if the tumor compresses the trachea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Firm, painless, enlarged lymph nodes in the neck<\/span><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;What causes thyroid cancer&#8221; tab_id=&#8221;1762173024473-a272b0a5-b2ac&#8221;][vc_column_text]<b>The exact cause of thyroid cancer remains unknown<\/b><span style=\"font-weight: 400;\">\u2014there is no clearly defined cause-and-effect relationship.<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">However, several <\/span><b>risk factors<\/b><span style=\"font-weight: 400;\"> are recognized:<\/span><\/p>\n<ul>\n<li><b> <\/b><b>Radiation exposure.<\/b><span style=\"font-weight: 400;\"> Therapeutic or environmental exposure to radiation, particularly in the head and neck region during childhood, significantly increases the risk. Examples include radiation from medical treatments, nuclear accidents (e.g., Chernobyl), etc.<\/span><\/li>\n<li><b> Family history and genetic factors.<\/b><span style=\"font-weight: 400;\"> Having first-degree relatives with thyroid cancer increases the likelihood of developing the disease. Additionally, certain genetic mutations, such as in the RET gene, are associated with medullary thyroid carcinoma.<\/span><\/li>\n<li><b> Sex and age.<\/b><span style=\"font-weight: 400;\"> Thyroid cancer occurs more frequently in women and typically appears in middle-aged individuals.<\/span><\/li>\n<li><b> Thyroid disorders.<\/b><span style=\"font-weight: 400;\"> The presence of autoimmune thyroid diseases, such as Hashimoto\u2019s thyroiditis, and the existence of goiter are linked to an increased risk of thyroid cancer.<\/span><\/li>\n<li><b> Obesity.<\/b><span style=\"font-weight: 400;\"> Excess body weight has also been associated with a higher probability of developing thyroid cancer.<\/span><\/li>\n<li><b> Stress.<\/b><span style=\"font-weight: 400;\"> Numerous scientific discussions and studies suggest a connection between stress, psychological factors, and carcinogenesis.<\/span><\/li>\n<li><b> Association with other cancers.<\/b><span style=\"font-weight: 400;\"> Women with a history of breast cancer have a 55% higher risk of developing thyroid cancer compared with the general population.<\/span><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;How is thyroid cancer diagnosed&#8221; tab_id=&#8221;1762173135402-a9a03df8-2900&#8243;][vc_column_text]<b>Diagnosis<\/b><span style=\"font-weight: 400;\"> involves a combination of clinical assessment and specialized tests:<\/span><\/p>\n<ul>\n<li><b><\/b><b> Medical history and clinical examination. <\/b><span style=\"font-weight: 400;\">This includes a detailed personal and family medical history. Clinical palpation of the neck by the physician unfortunately detects only about 4% of all thyroid nodules that are palpable, while also assessing for enlarged lymph nodes.<\/span><\/li>\n<li><b> Thyroid and neck ultrasound.<\/b><span style=\"font-weight: 400;\"> This is the most sensitive and specific imaging method for detecting suspicious thyroid nodules. Concerning ultrasound features include microcalcifications, increased vascularity, hypoechogenicity, irregular margins, and others. It is important to emphasize that small size alone does not indicate benignity \u2014 nowadays, very small thyroid carcinomas are often discovered that may still exhibit aggressive biological behavior.<\/span><\/li>\n<li><b> Fine-needle aspiration (FNA).<\/b><span style=\"font-weight: 400;\"> This is the primary test for cytological confirmation of malignancy. It is noteworthy that FNA provides limited information based on a small cell sample, and therefore may not always represent the condition of the entire gland.<\/span><\/li>\n<li><b> Blood tests.<\/b><span style=\"font-weight: 400;\"> Unfortunately, there are no specific biochemical markers for thyroid cancer, except for <\/span><b>calcitonin<\/b><span style=\"font-weight: 400;\">, which is used in cases of medullary thyroid carcinoma. It should be clearly stated that in the vast majority of thyroid cancer cases, thyroid hormone levels (T3, T4, TSH) remain within normal range.<\/span><\/li>\n<li><b> Elastography.<\/b><span style=\"font-weight: 400;\"> This ultrasound technique evaluates the stiffness of the nodule, helping to some extent in assessing the probability of malignancy.<\/span><\/li>\n<li><b> Additional imaging studies.<\/b><span style=\"font-weight: 400;\"> In selected cases, CT\/MRI scans or thyroid scintigraphy (for functional assessment and detection of metastases) may be required. In most cases, however, the information obtained from ultrasound alone is sufficient.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In general, diagnosis typically begins with the incidental or targeted discovery of a suspicious nodule, followed by diagnostic tests for accurate characterization and staging of the cancer. Diagnostic assessment is further enhanced by:<\/span><\/p>\n<ul>\n<li><b>Neck ultrasound mapping<\/b><span style=\"font-weight: 400;\">, performed by a specialized radiologist, to detect possible lymph node involvement and assist the surgeon in planning the procedure.<\/span><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;What preventive measures can I take&#8221; tab_id=&#8221;1615975590436-b57265fb-fab9&#8243;][vc_column_text]<span style=\"font-weight: 400;\">Since the exact cause is unknown, there are <\/span><b>no specific primary prevention measures<\/b><span style=\"font-weight: 400;\"> beyond a healthy lifestyle.<\/span><\/p>\n<p><b>Early detection is crucial.<\/b><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">Because thyroid cancer <\/span><b>usually causes no symptoms<\/b><span style=\"font-weight: 400;\"> and does <\/span><b>not alter thyroid hormone levels<\/b><span style=\"font-weight: 400;\">, incorporating a <\/span><b>thyroid ultrasound<\/b><span style=\"font-weight: 400;\"> into your <\/span><b>annual preventive check-up<\/b><span style=\"font-weight: 400;\"> is highly recommended.<\/span>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;What types of thyroid cancer exist&#8221; tab_id=&#8221;1615975556038-9e4b248f-329d&#8221;][vc_column_text]<span style=\"font-weight: 400;\">Based on cellular origin and histological features, the main types are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Papillary thyroid carcinoma (PTC)<\/b><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">The most common type. Originates from follicular cells, may affect any age group, grows slowly, has an excellent prognosis, and may require radioactive iodine therapy in select cases.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Follicular thyroid carcinoma (FTC)<\/b><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">Less common than PTC, occurs more frequently in women over 40, and is slightly more aggressive.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>H\u00fcrthle cell carcinoma<\/b><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">A rare variant, 4% of cases, originating from H\u00fcrthle cells, with behavior similar to follicular carcinoma.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Medullary thyroid carcinoma (MTC)<\/b><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">Represents 3\u20135% of cases, arises from parafollicular (C) cells that produce calcitonin, may be sporadic or hereditary, and does not respond to radioactive iodine.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Anaplastic thyroid carcinoma<\/b><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">Very rare, highly aggressive, more common in the elderly, with poor prognosis.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Thyroid lymphoma<\/b><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">Also rare, originating from lymphocytes; often treated with radiotherapy and chemotherapy.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">PTC and FTC are the most common types and generally have an excellent prognosis.<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><b>Timely and proper surgical treatment<\/b><span style=\"font-weight: 400;\"> offers <\/span><b>complete cure<\/b><span style=\"font-weight: 400;\"> in the vast majority of cases.<\/span>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;What is medullary thyroid carcinoma&#8221; tab_id=&#8221;1615976016751-0a946bcb-71fc&#8221;][vc_column_text]<span style=\"font-weight: 400;\">Medullary thyroid carcinoma (MTC) is a rare form of thyroid cancer. It can occur spontaneously or as part of genetic syndromes such as <\/span><b>Multiple Endocrine Neoplasia type 2 (MEN2)<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Diagnosis is closely linked to elevated <\/span><b>calcitonin<\/b><span style=\"font-weight: 400;\"> levels. Although more aggressive than follicular-derived cancers, it can be successfully treated surgically with appropriately planned radical operations. If there is a family history, genetic counseling and testing for both the patient and relatives are essential.<\/span><\/p>\n<p><b>It is noteworthy that in cases of mild elevation of calcitonin levels, timely surgical removal of the thyroid gland provides a definitive solution and cure. This intervention prevents disease progression at a benign precancerous stage known as C-cell hyperplasia.<\/b>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;What are the stages of thyroid cancer&#8221; tab_id=&#8221;1615976104393-438a3c43-b7c5&#8243;][vc_column_text]<span style=\"font-weight: 400;\">The stages of thyroid cancer are determined using the <\/span><b>international TNM classification system,<\/b><span style=\"font-weight: 400;\"> which assesses the local extent of the tumor (T), lymph node involvement (N), and the presence of distant metastases (M), categorizing the disease from stage 0 to stage IV.<\/span><\/p>\n<p><b>Tumor staging plays a critical role in predicting prognosis and ensuring good survival outcomes. Early removal of suspicious lesions\u2014those that raise even the slightest concern for malignancy (\u201cgray zones\u201d)\u2014offers the optimal opportunity to intervene while the disease is still benign and precancerous, or at most in its very early malignant phase. This approach enables complete and effective treatment, allowing patients to continue their lives with confidence and normalcy.<\/b>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Can thyroid cancer spread to other organs&#8221; tab_id=&#8221;1615976152058-1fb10f02-c563&#8243;][vc_column_text]<span style=\"font-weight: 400;\">Most common thyroid cancers <\/span><b>do not metastasize<\/b><span style=\"font-weight: 400;\"> to distant organs. They usually grow slowly and remain localized. If the tumor extends beyond the thyroid capsule, it may involve nearby lymph nodes\u2014a surgically treatable condition.<\/span>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Is thyroid cancer hereditary&#8221; tab_id=&#8221;1615976199009-15cf9489-9ec0&#8243;][vc_column_text]<span style=\"font-weight: 400;\">In most cases, thyroid cancer <\/span><b>is not hereditary.<\/b><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">Genetic predisposition may be present mainly in <\/span><b>medullary thyroid cancer<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, whenever thyroid cancer occurs in a family, preventive ultrasound screening of first-degree relatives is recommended.<\/span>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;How is thyroid cancer treated&#8221; tab_id=&#8221;1615976245890-84af2470-7a35&#8243;][vc_column_text]<b>Surgery<\/b><span style=\"font-weight: 400;\">, performed by an experienced endocrine surgeon, is the <\/span><b>primary treatment.<\/b><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">It may involve <\/span><b>partial or total <a href=\"https:\/\/endocrinesurgeon.gr\/en\/thyroidectomy\/\">thyroidectomy<\/a><\/b><span style=\"font-weight: 400;\">, often combined with neck lymph-node dissection if needed.<\/span><\/p>\n<p><b>Radioactive iodine therapy (I-131)<\/b><span style=\"font-weight: 400;\"> may be used postoperatively in selected cases according to international guidelines, to destroy remaining thyroid cancer cells.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">At this point, it should be emphasized how <\/span><b>greatly the patient benefits from the timely removal of the neoplastic thyroid. By intervening early, according to international guidelines, the patient may avoid the need for radioactive iodine therapy and the associated burden of isolation.<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Other treatments, such as radiotherapy or chemotherapy, are rarely required.<\/span>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Should I worry about thyroid cancer&#8221; tab_id=&#8221;1615976319511-f293f35c-5a98&#8243;][vc_column_text]<b>No. <\/b><span style=\"font-weight: 400;\">The <\/span><b>prognosis<\/b><span style=\"font-weight: 400;\"> for the most common thyroid cancers is excellent. Therefore, a patient diagnosed with thyroid cancer has every reason to be optimistic, as timely and specialized surgical treatment can <\/span><b>completely overcome the disease, allowing for a normal and healthy life.<\/b><\/p>\n<p><b>Dr. Evangelos Karvounis, MD, PhD, FACS<\/b><span style=\"font-weight: 400;\">, is an award-winning <\/span><a href=\"https:\/\/endocrinesurgeon.gr\/en\/\"><span style=\"font-weight: 400;\">endocrine surgeon<\/span><\/a><span style=\"font-weight: 400;\">, Doctor of the Medical School of the University of Athens and Fellow of the American College of Surgeons.<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">With expertise in robotic surgery and <\/span><b>many years of experience,<\/b><span style=\"font-weight: 400;\"> he currently serves as the Director of Endocrine Surgery at the Euroclinic Athens, where he applies advanced microsurgical techniques.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dr. Karvounis is well-equipped to answer any questions regarding thyroid cancer and is a top choice for safe and effective thyroid and parathyroid procedures. <\/span><a href=\"https:\/\/endocrinesurgeon.gr\/en\/contact\/\"><span style=\"font-weight: 400;\">Contact <\/span><\/a><span style=\"font-weight: 400;\">him today, either by phone or by completing the contact form, to schedule a consultation for<\/span><b> accurate diagnosis<\/b><span style=\"font-weight: 400;\"> and <\/span><b>personalized treatment<\/b><span style=\"font-weight: 400;\">.\u201d<\/span>[\/vc_column_text][\/vc_tta_section][\/vc_tta_accordion][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] \u0395\u03ba\u03c4\u03cd\u03c0\u03c9\u03c3\u03b7 [\/vc_column_text][vc_tta_accordion color=&#8221;sky&#8221; c_icon=&#8221;chevron&#8221; active_section=&#8221;1&#8243; no_fill=&#8221;true&#8221; collapsible_all=&#8221;true&#8221;][vc_tta_section title=&#8221;What is thyroid cancer&#8221; tab_id=&#8221;1615975356574-814f1578-a50b&#8221;][vc_column_text]Thyroid cancer is a malignant neoplasm originating in the thyroid gland\u2014an endocrine gland located at the base of the neck that produces essential hormones. It is the most common cancer of the endocrine system. It usually appears as a nodule or swelling in&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-16001","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Thyroid Cancer: Symptoms, Diagnosis &amp; Treatment | Karvounis<\/title>\n<meta name=\"description\" content=\"Thyroid cancer is often asymptomatic and curable. 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